The registry follows a hub and spoke model with primary data being collected in the electronic data capture form by satellite centres (dedicated COVID-19 hospitals) which are being trained, mentored and supervised by medical institutes of national repute chosen region-wise. In the first phase, 50 satellite centres and 14 registry sites have been included. The Central Implementation Committees have been constituted to provide supportive supervision. A steering committee of experts is in place to provide overarching guidance.

Data management including the development of the electronic data capture form is being done by ICMR-National Institute of Medical Statistics (NIMS).